Migalomorphic spiders venom: extraction and investigation of biological activity

Abstract

A number of researchers have noted that spiders produce a venom consisting of a mixture of potent selective toxins of different nature (from salts to large multi-domain proteins), each of which can have its own specific biological activity. A wide range of similar substances has been presented in venom of spiders which are an admixture of potent and selective toxins, each of which can have a specific biological activity. Considering the action mechanisms of venom, it is logical to assume that among the components of a poison of spiders, the peptides possessing antimicrobial activity can be found. From this point of view, mygalomorph spiders have been the most interesting to be studied. 24 mygalomorph spiders from 12 genera were studied to identify the influence of electrical stimulation parameters on the venom extracting. Electrical stimulation with various parameters allowed determining the spiders with the best ability of venom extracting. The selected venom was studied for insecticide and bactericide activity