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https://dspace.ncfu.ru/handle/20.500.12258/3429
Title: | Catalyst-free Biginelli-type synthesis of new functionalized 4,7-dihydropyrazolo[1,5-: A] pyrimidines |
Authors: | Dotsenko, V. V. Доценко, В. В. |
Keywords: | Aldehyde derivative;Carbene;Carbonyl derivative;Cyanide;Cyclohexane derivative;Pyrazolopyrimidine derivative;Quinazoline derivative;Synthesis |
Issue Date: | 2016 |
Publisher: | Royal Society of Chemistry |
Citation: | Kolosov, M.A., Beloborodov, D.A., Orlov, V.D., Dotsenko, V.V. Catalyst-free Biginelli-type synthesis of new functionalized 4,7-dihydropyrazolo[1,5-: A] pyrimidines // New Journal of Chemistry. - 2016. - Volume 40. - Issue 9. - Pages 7573-7579 |
Series/Report no.: | New Journal of Chemistry |
Abstract: | The Biginelli-type reaction of 5-amino-3-arylpyrazole-4-carbonitriles with aldehydes and 1,3-dicarbonyl compounds was studied in detail. We found that the reaction requires no catalysts and proceeds in boiling DMF to give 2-aryl-6-RC(O)-4,7-dihydropyrazolo[1,5-a]pyrimidin-3-carbonitriles in good yields. The reaction of aminopyrazoles with dicarbonyls leading to 6-unsubstituted pyrazolo[1,5-a]pyrimidines proceeds competitively and becomes the dominant process under acid-promoted conditions. 2-Aryl-8-oxo-4,5,6,7,8,9-hexahydropyrazolo[5,1-b]quinazolin-3-carbonitriles were obtained under catalyst-free conditions in up to 80% yields starting from 5-amino-3-arylpyrazole-4-carbonitriles, aldehydes and 1,3-cyclohexanedione |
URI: | https://www.scopus.com/record/display.uri?eid=2-s2.0-84985023389&origin=resultslist&sort=plf-f&src=s&nlo=1&nlr=20&nls=afprfnm-t&affilName=north+caucasus+federal+university&sid=4deb6b7c4ec3f54375d585c101df8694&sot=afnl&sdt=sisr&sl=53&s=%28AF-ID%28%22North+Caucasus+Federal+University%22+60070541%29%29&ref=%28Catalyst-free+Biginelli-type+synthesis+of+new+functionalized+4%2c7-dihydropyrazolo%5b1%2c5-%3a+A%5d+pyrimidines%29&relpos=0&citeCnt=2&searchTerm= http://hdl.handle.net/20.500.12258/3429 |
Appears in Collections: | Статьи, проиндексированные в SCOPUS, WOS |
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scopusresults 595 .pdf Restricted Access | 62.3 kB | Adobe PDF | View/Open | |
WoS 342 .pdf Restricted Access | 1.47 MB | Adobe PDF | View/Open |
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