Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12258/3475
Title: A nitroalkane-based approach to one-pot three-component synthesis of isocryptolepine and its analogs with potent anti-cancer activities
Authors: Aksenov, N. A.
Аксенов, Н. А.
Aksenov, A. V.
Аксенов, А. В.
Aksenov, D. A.
Аксенов, Д. А.
Ovcharov, S. N.
Овчаров, С. Н.
Rubin, M. A.
Рубин, М. А.
Keywords: Anticancer activity;Change operations;Concise synthesis;Polyphosphoric acids;Second generation;Synthetic analogs;Synthetic application;Three component
Issue Date: 2018
Publisher: ROYAL SOC CHEMISTRY
Citation: Aksenov, N.A., Aksenov, A., Kornienko, A., De Carvalho, A., Mathieu, V., Aksenov, D.A., Ovcharov, S.N., Griaznov, G.D., Rubin, M. A nitroalkane-based approach to one-pot three-component synthesis of isocryptolepine and its analogs with potent anti-cancer activities // RSC Advances. - 2018. - Volume 8. - Issue 64. - Pages 36980-36986
Series/Report no.: RSC Advances
Abstract: A second generation polyphosphoric acid-mediated one-pot three-component synthesis of indoloquinoline scaffold is developed. This improved version of the process involves electrophilically activated nitroalkanes for the installation of strategic C-C and C-N bonds and ring C assembly. This modification allows the elimination of unnecessary solvent change operations and all steps are carried out in a true, uninterrupted one-pot manner. A further improvement involves the possibility to install an ortho-amino group in situ. A synthetic application of this method is showcased by the concise synthesis of an isocryptolepine alkaloid and its synthetic analogs with potent anticancer activities
URI: https://www.scopus.com/record/display.uri?eid=2-s2.0-85056392927&origin=resultslist&sort=plf-f&src=s&st1=A+nitroalkane-based+approach+to+one-pot+three-component+synthesis+of+isocryptolepine+and+its+analogs+with+potent+anti-cancer+activities&st2=&sid=24b550a4004eff540c1f66bf75dbf431&sot=b&sdt=b&sl=150&s=TITLE-ABS-KEY%28A+nitroalkane-based+approach+to+one-pot+three-component+synthesis+of+isocryptolepine+and+its+analogs+with+potent+anti-cancer+activities%29&relpos=0&citeCnt=0&searchTerm=
http://hdl.handle.net/20.500.12258/3475
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