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Title: | Synthesis and properties of 4,6-Dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile and 3-Amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines |
Authors: | Dotsenko, V. V. Доценко, В. В. Aksenov, N. A. Аксенов, Н. А. Aksenova, I. V. Аксенова, И. В. |
Keywords: | 1,3,2λ5-diazaphosphinines;Cyanothioacetamide;In silico biological activity;Lipophilicity;Thieno[2,3-b]pyridines;Thorpe-Ziegler cyclization |
Issue Date: | 2019 |
Publisher: | Pleiades Publishing |
Citation: | Buryi, D.S., Dotsenko, V.V., Aksenov, N.A., Aksenova, I.V., Krivokolysko, S.G., Dyadyuchenko, L.V. Synthesis and Properties of 4,6-Dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile and 3-Amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines // Russian Journal of General Chemistry. - 2019. - Volume 89. - Issue 8. - Pages 1575-1585 |
Series/Report no.: | Russian Journal of General Chemistry |
Abstract: | The reaction of 3-pentylpentane-2,4-dione with cyanothioacetamide afforded 4,6-dimethyl-5-pentyl-2-thioxo-1,2-dihydropyridine-3-carbonitrile. Alkylation of the latter led to the formation of 2-alkylsulfanyl-4,6-dimethyl-5-pentylpyridine-3-carbonitriles or 3-amino-4,6-dimethyl-5-pentylthieno[2,3-b]pyridines, depending on the alkylating agent and reaction conditions. The structures of the key compounds were proved by 2D NMR spectroscopy and X-ray analysis. Biological activity of the synthesized compounds was evaluated in silico. Some compounds were experimentally found to stimulate growth of sunflower seedlings |
URI: | https://www.scopus.com/record/display.uri?eid=2-s2.0-85073000711&origin=resultslist&sort=plf-f&src=s&st1=Synthesis+and+Properties+of+4%2c6-Dimethyl-5-pentyl-2-thioxo-1%2c2-dihydropyridine-3-carbonitrile+and+3-Amino-4%2c6-dimethyl-5-pentylthieno&st2=&sid=a07413b3d3e0280d7630b8ca0d7daa23&sot=b&sdt=b&sl=148&s=TITLE-ABS-KEY%28Synthesis+and+Properties+of+4%2c6-Dimethyl-5-pentyl-2-thioxo-1%2c2-dihydropyridine-3-carbonitrile+and+3-Amino-4%2c6-dimethyl-5-pentylthieno%29&relpos=0&citeCnt=0&searchTerm= http://hdl.handle.net/20.500.12258/8004 |
Appears in Collections: | Статьи, проиндексированные в SCOPUS, WOS |
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scopusresults 1027 .pdf Restricted Access | 785.23 kB | Adobe PDF | View/Open | |
WoS 696 .pdf Restricted Access | 76.52 kB | Adobe PDF | View/Open |
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