THE CORRELATION OF METABOLIC AND PLATE LET INDICATORS IN PATIENTS WITH HEREDITARY THROMBOPHILIA

Abstract

Patients with the A2 polymorphism of the subunit gene of glycoprotein IIb/IIIa platelet receptors showed an increased level of endothelial dysfunction markers and increased free-radical reactions, as well as an increase in the geometric parameters of platelets, an increase in their functional activity and the appearance of young cells in peripheral blood. A correlation was found between the parameters of platelet hemostasis and the severity of free-radical reactions in women patients with thrombophilia who have A2 polymorphism in the gene of the subunits of the platelet receptor glycoprotein IIb/IIIa