Репозиторий научных и учебно-методических публикаций
ФГАОУ ВО «Северо-Кавказский федеральный университет»
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https://dspace.ncfu.ru/handle/20.500.12258/11979| Title: | Electrophilic alkylation of arenes with 5-bromopyrimidine en route to 4-aryl-5-alkynylpyrimidines |
| Authors: | Shcherbakov, S. V. Щербаков, С. В. Magometov, A. Y. Магометов, А. Ю. Shcherbakova, V. Y. Щербакова, В. Ю. Aksenov, A. V. Аксенов, А. В. Rubin, M. A. Рубин, М. А. |
| Keywords: | Aromatic hydrocarbons;Catalysis;Electrophilic alkylations;Synthetic protocols;Alkylation;Palladium-catalyzed |
| Issue Date: | 2020 |
| Publisher: | Royal Society of Chemistry |
| Citation: | Shcherbakov, S.S., Magometov, A.Y., Shcherbakova, V.Y., Aksenov, A.V., Domenyuk, D.A., Zelensky, V.A., Rubin, M. Electrophilic alkylation of arenes with 5-bromopyrimidine en route to 4-aryl-5-alkynylpyrimidines // RSC Advances. - 2020. - Volume 10. - Issue 17. - Pages 10315-10321 |
| Series/Report no.: | RSC Advances |
| Abstract: | A new synthetic protocol for preparation of medicinally important 4-aryl-5-alkynylpyrimidines is described. The featured approach involves a sequence of chemo- and regioselective Brønsted acid-catalyzed electrophilic alkylation of arenes with 5-bromopyrimidine, followed by oxidative re-aromatization of the formed dihydropyrimidine ring. Finally, palladium-catalyzed Sonogashira cross-coupling reaction provided an end-game strategy |
| URI: | http://hdl.handle.net/20.500.12258/11979 |
| Appears in Collections: | Статьи, проиндексированные в SCOPUS, WOS |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| WoS 801 .pdf Restricted Access | 189.98 kB | Adobe PDF | View/Open | |
| scopusresults 1232 .pdf Restricted Access | 133.89 kB | Adobe PDF | View/Open |
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