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Title: Electrophilic alkylation of arenes with 5-bromopyrimidine en route to 4-aryl-5-alkynylpyrimidines
Authors: Shcherbakov, S. V.
Щербаков, С. В.
Magometov, A. Y.
Магометов, А. Ю.
Shcherbakova, V. Y.
Щербакова, В. Ю.
Aksenov, A. V.
Аксенов, А. В.
Rubin, M. A.
Рубин, М. А.
Keywords: Aromatic hydrocarbons;Catalysis;Electrophilic alkylations;Synthetic protocols;Alkylation;Palladium-catalyzed
Issue Date: 2020
Publisher: Royal Society of Chemistry
Citation: Shcherbakov, S.S., Magometov, A.Y., Shcherbakova, V.Y., Aksenov, A.V., Domenyuk, D.A., Zelensky, V.A., Rubin, M. Electrophilic alkylation of arenes with 5-bromopyrimidine en route to 4-aryl-5-alkynylpyrimidines // RSC Advances. - 2020. - Volume 10. - Issue 17. - Pages 10315-10321
Series/Report no.: RSC Advances
Abstract: A new synthetic protocol for preparation of medicinally important 4-aryl-5-alkynylpyrimidines is described. The featured approach involves a sequence of chemo- and regioselective Brønsted acid-catalyzed electrophilic alkylation of arenes with 5-bromopyrimidine, followed by oxidative re-aromatization of the formed dihydropyrimidine ring. Finally, palladium-catalyzed Sonogashira cross-coupling reaction provided an end-game strategy
Appears in Collections:Статьи, проиндексированные в SCOPUS, WOS

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