Репозиторий научных и учебно-методических публикаций
ФГАОУ ВО «Северо-Кавказский федеральный университет»
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https://dspace.ncfu.ru/handle/20.500.12258/14853| Title: | Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence |
| Authors: | Aksenov, A. V. Аксенов, А. В. Aksenov, D. A. Аксенов, Д. А. Aksenov, N. A. Аксенов, Н. А. Skomorokhov, A. A. Скоморохов, А. А. Aleksandrova, E. V. Александрова, Е. В. Rubin, M. A. Рубин, М. А. |
| Keywords: | Addition reactions;Reagents;Alkyl-substituted derivatives;Polycyclic aromatic hydrocarbons |
| Issue Date: | 2021 |
| Publisher: | Royal Society of Chemistry |
| Citation: | Aksenov, A.V., Aksenov, D.A., Aksenov, N.A., Skomorokhov, A.A., Aleksandrova, E.V., Rubin, M. Preparation of spiro[indole-3,5′-isoxazoles] via Grignard conjugate addition/spirocyclization sequence // RSC Advances. - 2021. - Volume 11. - Issue 3. - Pages 1783-1793 |
| Series/Report no.: | RSC Advances |
| Abstract: | A highly efficient one-pot procedure combining conjugate addition of Grignard reagents to (2-nitroalkenyl)indoles and sub-sequent Brønsted acid-assisted spirocyclization allowed for preparation of 4′H-spiro[indole-3,5′-isoxazoles] in a diastereomerically selective fashion. Utilization of alkyl Grignard reagents provided an easy access to 4′-alkylsubstituted derivatives hardly available by other means |
| URI: | http://hdl.handle.net/20.500.12258/14853 |
| Appears in Collections: | Статьи, проиндексированные в SCOPUS, WOS |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| scopusresults 1540 .pdf Restricted Access | 866.19 kB | Adobe PDF | View/Open | |
| WoS 1003 .pdf Restricted Access | 259.08 kB | Adobe PDF | View/Open |
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