Please use this identifier to cite or link to this item: http://hdl.handle.net/20.500.12258/18098
Title: [3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor
Authors: Aksenov, A. V.
Аксенов, А. В.
Arutiunov, N. A.
Арутюнов, Н. А.
Kirilov, N. K.
Кирилов, Н. К.
Aksenov, D. A.
Аксенов, Д. А.
Grishin, I. Y.
Гришин, И. Ю.
Aksenov, N. A.
Аксенов, Н. А.
Rubin, M. A.
Рубин, М. А.
Keywords: Indolizines;Pyrazolo[1,5-a]pyridines;Indolizine 9db;Anticancer agents
Issue Date: 2021
Publisher: Royal Society of Chemistry
Citation: Aksenov, A. V.; Arutiunov, N. A.; Kirilov, N. K.; Aksenov, D. A.; Grishin, I. Y.; Aksenov, N. A.; Wang, H.; Du, L.; Betancourt, T.; Pelly, S. C.; Kornienko, A.; Rubin, M. [3 + 2]-Annulation of pyridinium ylides with 1-chloro-2-nitrostyrenes unveils a tubulin polymerization inhibitor // Organic and Biomolecular Chemistry. - 2021. - Том 19. - Выпуск 33. - Стр.: 7234 - 7245
Series/Report no.: Organic and Biomolecular Chemistry
Abstract: Indolizines and pyrazolo[1,5-a]pyridines were prepared via [3 + 2]-cycloaddition of pyridinium ylides to 1-chloro-2-nitrostyrenes. The synthesized molecules were evaluated for antiproliferative activities against a BE(2)-C neuroblastoma cell line with several compounds decreasing the viability of cancer cells. Indolizine 9db showed higher potency than that of all-trans-retinoic acid, an approved cancer drug. Mechanistically, it was found to inhibit tubulin polymerization and it is thus proposed that the discovered chemistry can be exploited for the development of novel microtubule-targeting anticancer agents
URI: http://hdl.handle.net/20.500.12258/18098
Appears in Collections:Статьи, проиндексированные в SCOPUS, WOS

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