Direct conversion of 3-(2-nitroethyl)-1H-indoles into 2-(1H-indol-2-yl)acetonitriles

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Title:	Direct conversion of 3-(2-nitroethyl)-1H-indoles into 2-(1H-indol-2-yl)acetonitriles
Authors:	Aksenov, A. V. Аксенов, А. В. Aksenov, N. A. Аксенов, Н. А. Aleksandrova, E. V. Александрова, Е. В. Aksenov, D. A. Аксенов, Д. А. Grishin, I. Y. Гришин, И. Ю. Rubin, M. A. Рубин, М. А.
Keywords:	Nitroalkanes;Cascade transformations;Heterocycles;1,2-alkyl shift;Rearrangements
Issue Date:	2021
Publisher:	MDPI
Citation:	Aksenov, A.V., Aksenov, N.A., Aleksandrova, E.V., Aksenov, D.A., Grishin, I.Yu., Sorokina, E.A., Wenger, A., Rubin, M. Direct conversion of 3-(2-nitroethyl)-1H-indoles into 2-(1H-indol-2-yl)acetonitriles // Molecules, - 2021. - Том 26. - Выпуск 20. - Номер статьи 6132. - DOI: 10.3390/molecules26206132
Series/Report no.:	Molecules
Abstract:	The recently discovered [4+1]-spirocyclization of nitroalkenes to indoles provided a convenient new approach to 2-(1H-indol-2-yl)acetonitriles. However, this reaction was complicated by the formation of inert 3-(2-nitroethyl)-1H-indole byproducts. Herein, we offer a workaround this problem that allows for effective transformation of the unwanted byproducts into acetonitrile target molecules.
URI:	http://hdl.handle.net/20.500.12258/18235
Appears in Collections:	Статьи, проиндексированные в SCOPUS, WOS

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