Morphofunctional condition of bones and hippocampus of white rats at experimental intoxication with aluminium chloride

Abstract

It is established that use of aluminium chloride in a dose of 100 mg/kg Bw brings essential changes in the CNS and skeletal system. So, there are essential changes in population of neurons of a hippocampus of rats, particularly, the significant increase of the quantity of chromatolyzed, hyperchromic and wrinkled neurons. Such changes in general are a characteristic symptom of Alzheimer's disease. At the same time, decrease in trabecular bone mineral density at Al-treated rats against the background of the pattern of change of the value BV/TV demonstrates that trabecular bone mineral density goes down due to reduction of salts of calcium in favor of what also increase in level of a calcaemia at animals of this group testifies. Thus, the influence of AlCl3 leads to a decrease in trabecular bone mineral density, and, as a result, to development of hypercalcaemia